What is the optimal number of neoadjuvant chemotherapy cycles for resectable colorectal liver oligometastases?

ABSTRACT:

Background

The optimal number of neoadjuvant chemotherapy (NAC) cycles for resectable colorectal liver oligometastases (CLOM) remains unclear. The aim of this study was to investigate the optimal number of NAC cycles.

Methods

One hundred twenty-nine consecutive patients were included in this study. X-tile analysis was implemented to investigate the optimal cut-off point for NAC cycles. Propensity score matching was performed to reduce selection bias. Kaplan-Meier curves and Cox risk regression models were used to analyse progression-free survival (PFS) and overall survival (OS).

Results

The optimal cut-off point for NAC cycles was 5. There were no significant differences in R0 resection, pathological response or postoperative complications between the groups with a lo

SUBMITTER: Chen Q 

PROVIDER: S-EPMC7859783 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature