Functional thalamocortical connectivity at term equivalent age and outcome at 2 years in infants born preterm.

ABSTRACT: Infants born preterm are at high risk of long-term motor and neurocognitive deficits. In the majority of these infants structural MRI at the time of normal birth does not predict motor or cognitive outcomes accurately, and many infants without apparent brain lesions later develop motor and cognitive deficits. Thalamocortical connections are known to be necessary for normal brain function; they develop during late fetal life and are vulnerable to perinatal adversity. This study addressed the hypothesis that abnormalities in the functional connectivity between cortex and thalamus underlie neurocognitive impairments seen after preterm birth. Using resting state functional connectivity magnetic resonance imaging (fMRI) in a group of 102 very preterm infants without major focal brain lesions, w

SUBMITTER: Toulmin H 

PROVIDER: S-EPMC7859832 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature