Association Between Statin Use at the Time of Intra-abdominal Surgery and Postoperative Adhesion-Related Complications and Small-Bowel Obstruction.

ABSTRACT:

Importance

Adhesion-related complications (ARCs), including small-bowel obstruction, are common complications of intra-abdominal surgery. Statins, which have antifibrotic pleiotropic effects, inhibit adhesion formation in murine models but have not been assessed in humans.

Objective

To assess whether statin use at the time of intra-abdominal surgery is associated with a reduction in ARCs.

Design, setting, and participants

These 2 separate retrospective cohort studies (The Health Improvement Network [THIN] and Optum's Clinformatics Data Mart [Optum]) compared adults receiving statins with those not receiving statins at the time of intra-abdominal surgery. Individuals undergoing intra-abdominal surgery from January 1, 1996, to December 31, 2013, in the United Kingdom an

SUBMITTER: Scott FI 

PROVIDER: S-EPMC7859844 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature