Genome-Wide Epigenetic Signatures of Adaptive Developmental Plasticity in the Andes.

ABSTRACT: High-altitude adaptation is a classic example of natural selection operating on the human genome. Physiological and genetic adaptations have been documented in populations with a history of living at high altitude. However, the role of epigenetic gene regulation, including DNA methylation, in high-altitude adaptation is not well understood. We performed an epigenome-wide DNA methylation association study based on whole blood from 113 Peruvian Quechua with differential lifetime exposures to high altitude (>2,500) and recruited based on a migrant study design. We identified two significant differentially methylated positions (DMPs) and 62 differentially methylated regions (DMRs) associated with high-altitude developmental and lifelong exposure statuses. DMPs and DMRs were found in genes asso

SUBMITTER: Childebayeva A 

PROVIDER: S-EPMC7859850 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature