Influence of the pK _a Value of Cinnamic Acid and P-Hydroxycinnamic Acid on the Solubility of a Lurasidone Hydrochloride-Based Coamorphous System.

ABSTRACT: Coamorphization of a poorly water-soluble active pharmaceutical ingredient (API) has been proven to be effective in improving its solubility. Generally, API can form multiple coamorphous systems with different coformers. However, it remains unclear how the pK _a value of different coformers influences the solubility of the API. In this study, structurally related cinnamic acid (CA, pK _a = 4.37) and p-hydroxycinnamic acid (pHCA, pK _a = 4.65) were chosen as coformers for the coamorphization of lurasidone hydrochloride (LH). To investigate the influence of the pK _a value of the coformers on the solubility of LH, LH-CA/pHCA coamorphous systems were prepared by the vacuum rotary evaporation method and characterized by

SUBMITTER: Hu Y 

PROVIDER: S-EPMC7860058 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature