A glucose-starvation response governs endocytic trafficking and eisosomal retention of surface cargoes in budding yeast.

ABSTRACT: Eukaryotic cells adapt their metabolism to the extracellular environment. Downregulation of surface cargo proteins in response to nutrient stress reduces the burden of anabolic processes whilst elevating catabolic production in the lysosome. We show that glucose starvation in yeast triggers a transcriptional response that increases internalisation from the plasma membrane. Nuclear export of the Mig1 transcriptional repressor in response to glucose starvation increases levels of the Yap1801 and Yap1802 clathrin adaptors, which is sufficient to increase cargo internalisation. Beyond this, we show that glucose starvation results in Mig1-independent transcriptional upregulation of various eisosomal factors. These factors serve to sequester a portion of nutrient transporters at existing eisosom

SUBMITTER: Laidlaw KME 

PROVIDER: S-EPMC7860119 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature