Association of a four-gene model with allergic diseases: Two-year follow-up of a birth cohort study.

ABSTRACT:

Background

Our previous study has developed a four-gene model involving IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108 associated with asthma and atopy in Chinese Han children. However, whether the gene model is associated with allergies in early life has yet to be determined. This study aimed to apply the gene model in a birth cohort to investigate its associations with the development of allergic diseases in Chinese Han toddlers.

Methods

Five hundred and ninety-seven children from a birth cohort completing 2-year follow-up were included. Epidemiologic information and cord blood were collected. Children were genotyped for the above polymorphisms and divided into high or low genetic risk groups based on the genotypes. Subjects were followed at 6, 12, and 2

SUBMITTER: Hua L 

PROVIDER: S-EPMC7860525 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature