Multi-trait association studies discover pleiotropic loci between Alzheimer's disease and cardiometabolic traits.

ABSTRACT:

Background

Identification of genetic risk factors that are shared between Alzheimer's disease (AD) and other traits, i.e., pleiotropy, can help improve our understanding of the etiology of AD and potentially detect new therapeutic targets. Previous epidemiological correlations observed between cardiometabolic traits and AD led us to assess the pleiotropy between these traits.

Methods

We performed a set of bivariate genome-wide association studies coupled with colocalization analysis to identify loci that are shared between AD and eleven cardiometabolic traits. For each of these loci, we performed colocalization with Genotype-Tissue Expression (GTEx) project expression quantitative trait loci (eQTL) to identify candidate causal genes.

Results

We identified three previo

SUBMITTER: Bone WP 

PROVIDER: S-EPMC7860582 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature