Anticancer and antimicrobial potential of enterocin 12a from Enterococcus faecium.

ABSTRACT:

Background

Increase in the number of infections caused by Gram-negative bacteria in neutropenic cancer patients has prompted the search for novel therapeutic agents having dual anticancer and antimicrobial properties. Bacteriocins are cationic proteins of prokaryotic origin that have emerged as one of the most promising alternative antimicrobial agents with applications as food preservatives and therapeutic agents. Apart from their antimicrobial activities, bacteriocins are also being explored for their anticancer potential.

Results

In this study, a broad-spectrum, cell membrane-permeabilizing enterocin with a molecular weight of 65 kDa was purified and characterized from the culture supernatant of vaginal Enterococcus faecium 12a. Enterocin 12a inhibited multidrug-resistant

SUBMITTER: Sharma P 

PROVIDER: S-EPMC7860584 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature