Reelin depletion protects against autoimmune encephalomyelitis by decreasing vascular adhesion of leukocytes.

ABSTRACT: Neuroinflammation as a result of immune cell recruitment into the central nervous system (CNS) is a key pathogenic mechanism of multiple sclerosis (MS). However, current anti-inflammatory interventions depleting immune cells or directly targeting their trafficking into the CNS can have serious side effects, highlighting a need for better immunomodulatory strategies. We detected increased Reelin concentrations in the serum of patients with MS, resulting in increased endothelial permeability to leukocytes through increased nuclear factor κB-mediated expression of vascular adhesion molecules. We thus investigated the prophylactic and therapeutic potential of Reelin immunodepletion in experimental autoimmune encephalomyelitis (EAE) and further validated the results in Reelin knockout mice. Rem

SUBMITTER: Calvier L 

PROVIDER: S-EPMC7860587 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature