Enhanced IgG₁ -mediated antibody response towards thymus-dependent immunization in CXCR1-deficient mice.

ABSTRACT:

Background

Chemokine receptors and their corresponding ligands are key players of immunity by regulation of immune cell differentiation and migration. CXCR1 is a high-affinity receptor for CXCL8. Differential expression of CXCR1 is associated with a variety of human pathologies including cancer and inflammatory diseases. While various studies have highlighted the importance of CXCR1-mediated CXCL8-sensing for neutrophil trafficking and function, its role in B-cell responses remains unsolved. Therefore, our aim was to investigate innate and adaptive antibody responses in CXCR1-deficient mice.

Methods

Cell populations of the spleen and the peritoneal cavity were identified and quantified via flow cytometry. To investigate thymus-independent (TI) and thymus-dependent (TD) antib

SUBMITTER: Jaufmann J 

PROVIDER: S-EPMC7860589 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature