Evidence and implications of pre-existing humoral cross-reactive immunity to SARS-CoV-2.

ABSTRACT:

Background

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged throughout the world. Building knowledge around Covid-19 is crucial to devise facts based approaches to respond efficiently against this pandemic.

Aim

We aimed to investigate pre-existing humoral cross-reactive immunity to SARS-CoV-2.

Method

We have tested the reactivity against SARS-CoV-2 nucleocapsid (N) antigen of sera collected from healthy healthcare volunteers in 2014. We assessed immunoglobulins reactive against SARS-CoV-2 N-antigen using a well-validated serological platform; Elecsys assay.

Results

Sera from 32 subjects (out of 135 [23.7%]) were reactive to SARS-CoV-2 N-antigen, suggesting the presence of anti-SARS-CoV-2 N-antigen antibodies.

Conclusion

Although t

SUBMITTER: Mveang Nzoghe A 

PROVIDER: S-EPMC7860591 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature