Data mining combined with experiments to validate CEP55 as a prognostic biomarker in colorectal cancer.

ABSTRACT:

Introduction

Colorectal cancer (CRC) is a common tumor with high morbidity and mortality. Current specific diagnosis regarding CRC remains complicated and costly, and specific diagnostic biomarkers are lacking.

Methods

To find potential diagnostic and prognostic biomarkers for CRC, we screened and analyzed many CRC sequencing data by The Cancer Genome Atlas Program and Gene Expression Omnibus, and validated that CEP55 may be a potential diagnostic biomarker for CRC by molecular cytological experiments and immunohistochemistry, among others.

Results

We found that CEP55 is upregulated in CRC tissues and tumor cells and can promote CRC proliferation and metastasis by activating the p53/p21 axis and that CEP55 mutations in tumor patients result in worse overall survival a

SUBMITTER: Lin K 

PROVIDER: S-EPMC7860595 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature