Associations of quantitative susceptibility mapping with Alzheimer's disease clinical and imaging markers.

ABSTRACT: Altered iron metabolism has been hypothesized to be associated with Alzheimer's disease pathology, and prior work has shown associations between iron load and beta amyloid plaques. Quantitative susceptibility mapping (QSM) is a recently popularized MR technique to infer local tissue susceptibility secondary to the presence of iron as well as other minerals. Greater QSM values imply greater iron concentration in tissue. QSM has been used to study relationships between cerebral iron load and established markers of Alzheimer's disease, however relationships remain unclear. In this work we study QSM signal characteristics and associations between susceptibility measured on QSM and established clinical and imaging markers of Alzheimer's disease. The study included 421 participants (234 male, me

SUBMITTER: Cogswell PM 

PROVIDER: S-EPMC7860631 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature