Establishment of Criteria for Molecular Differential Diagnosis of MPLC and IPM.

ABSTRACT:

Backgrounds

Differential diagnosis of multiple primary lung cancer (MPLC) and intrapulmonary metastasis (IPM) is one difficulty in lung cancer diagnosis, and crucial for establishment of treatment strategies and prognosis prediction. This study aims to establish the criteria for molecular differential diagnosis of synchronous MPLC and IPM by the next-generation sequencing (NGS) method.

Methods

Training cohort included 30 synchronous MPLC (67 samples) patients and 5 synchronous IPM (13 samples) patients with adenocarcinoma. Criteria of MPLC/IPM differential diagnosis were established by results from a NGS-based 605-gene panel test. Subsequently, 16 patients (36 samples) were recruited as the validation cohort to verify the criteria.

Results

IPM lesions showed a high de

SUBMITTER: Wang X 

PROVIDER: S-EPMC7860975 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature