Ontology highlight
ABSTRACT:
SUBMITTER: Haskins N
PROVIDER: S-EPMC7860981 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Haskins Nantaporn N Bhuvanendran Shivaprasad S Anselmi Claudio C Gams Anna A Kanholm Tomas T Kocher Kristen M KM LoTempio Jonathan J Krohmaly Kylie I KI Sohai Danielle D Stearrett Nathaniel N Bonner Erin E Tuchman Mendel M Morizono Hiroki H Jaiswal Jyoti K JK Caldovic Ljubica L
Frontiers in physiology 20210121
Mitochondrial enzymes involved in energy transformation are organized into multiprotein complexes that channel the reaction intermediates for efficient ATP production. Three of the mammalian urea cycle enzymes: N-acetylglutamate synthase (NAGS), carbamylphosphate synthetase 1 (CPS1), and ornithine transcarbamylase (OTC) reside in the mitochondria. Urea cycle is required to convert ammonia into urea and protect the brain from ammonia toxicity. Urea cycle intermediates are tightly channeled in and ...[more]