Autozygosity mapping and time-to-spontaneous delivery in Norwegian parent-offspring trios.

ABSTRACT: Parental genetic relatedness may lead to adverse health and fitness outcomes in the offspring. However, the degree to which it affects human delivery timing is unknown. We use genotype data from ≃25 000 parent-offspring trios from the Norwegian Mother, Father and Child Cohort Study to optimize runs of homozygosity (ROH) calling by maximizing the correlation between parental genetic relatedness and offspring ROHs. We then estimate the effect of maternal, paternal and fetal autozygosity and that of autozygosity mapping (common segments and gene burden test) on the timing of spontaneous onset of delivery. The correlation between offspring ROH using a variety of parameters and parental genetic relatedness ranged between -0.2 and 0.6, revealing the importance of the minimum number of genetic va

SUBMITTER: Sole-Navais P 

PROVIDER: S-EPMC7861013 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature