Mutational hotspots and conserved domains of SARS-CoV-2 genome in African population.

ABSTRACT:

Background

Since outbreak in December 2019, the highly infectious and pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over a million deaths globally. With increasing burden, the novel coronavirus has posed a dire threat to public health, social interaction, and global economy. Mutations in the SARS-CoV-2 genome are moderately evolving which might have contributed to its genome variability, transmission, replication efficiency, and virulence in different regions of the world.

Results

The present study elucidated the mutational landscape in the SARS-CoV-2 genome among the African populace, which may have contributed to the virulence, spread, and pathogenicity observed in the region. A total of 3045 SARS-CoV-2 complete protein sequences with t

SUBMITTER: Omotoso OE 

PROVIDER: S-EPMC7861160 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature