BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy.

ABSTRACT:

Objective

Clinical and biological correlates of resilience in major depressive disorder are scarce. We aimed to investigate the effect of the Val66Met polymorphism in the BDNF gene on resilience scores in major depressive disorder patients and evaluate the polymorphism's moderation effect on resilience scores in response to cognitive therapy.

Method

A total of 106 major depressive disorder patients were enrolled in this clinical randomized study. The Resilience Scale and the Hamilton Rating Scale for Depression were applied at baseline, post-treatment, and at six months of follow-up. Blood samples were obtained at baseline for molecular analysis.

Results

The baseline resilience scores were higher in patients with the Met allele (114.6±17.6) than in those with the Val/

SUBMITTER: Peters RB 

PROVIDER: S-EPMC7861181 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature