Identification and Characterization of Plasmin-Independent Thrombolytic Enzymes.

ABSTRACT:

Rationale

Current thrombolytic agents activate plasminogen to plasmin which triggers fibrinolysis to dissolve thrombi. Since plasmin is a nonspecific proteolytic enzyme, all of the current plasmin-dependent thrombolytics lead to serious hemorrhagic complications, demanding a new class of fibrinolytic enzymes independent from plasmin activation and undesirable side effects. We speculated that the mammalian version of bacterial heat-shock proteins could selectively degrade intravascular thrombi, a typical example of a highly aggregated protein mixture.

Objective

The objective of this study is to identify enzymes that can dissolve intravascular thrombi specifically without affecting fibrinogen and fibronectin so that the wound healing processes remain uninterrupted and tissues

SUBMITTER: Hassan MM 

PROVIDER: S-EPMC7861503 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature