Neuropathology of COVID-19 (neuro-COVID): clinicopathological update.

ABSTRACT: Coronavirus disease 2019 (COVID-19) is emerging as the greatest public health crisis in the early 21^stcentury. Its causative agent, Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), is an enveloped single stranded positive-sense ribonucleic acid virus that enters cells via the angiotensin converting enzyme 2 receptor or several other receptors. While COVID-19 primarily affects the respiratory system, other organs including the brain can be involved. In Western clinical studies, relatively mild neurological dysfunction such as anosmia and dysgeusia is frequent (~70-84%) while severe neurologic disorders such as stroke (~1-6%) and meningoencephalitis are less common. It is unclear how much SARS-CoV-2 infection contributes to the incidence of stroke given co-morbidities

SUBMITTER: Lou JJ 

PROVIDER: S-EPMC7861505 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature