Episodic evolution of coadapted sets of amino acid sites in mitochondrial proteins.

ABSTRACT: The rate of evolution differs between protein sites and changes with time. However, the link between these two phenomena remains poorly understood. Here, we design a phylogenetic approach for distinguishing pairs of amino acid sites that evolve concordantly, i.e., such that substitutions at one site trigger subsequent substitutions at the other; and also pairs of sites that evolve discordantly, so that substitutions at one site impede subsequent substitutions at the other. We distinguish groups of amino acid sites that undergo coordinated evolution and evolve discordantly from other such groups. In mitochondrion-encoded proteins of metazoans and fungi, we show that concordantly evolving sites are clustered in protein structures. By analysing the phylogenetic patterns of substitutions at co

SUBMITTER: Neverov AD 

PROVIDER: S-EPMC7861529 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature