Pharmacological strategies to prevent postoperative delirium: a systematic review and network meta-analysis.

ABSTRACT:

Background

Postoperative delirium (POD) is a condition of cerebral dysfunction and a common complication after surgery. This study aimed to compare and determine the relative efficacy of pharmacological interventions for preventing POD using a network meta-analysis.

Methods

We performed a systematic and comprehensive search to identify and analyze all randomized controlled trials until June 29, 2020, comparing two or more pharmacological interventions, including placebo, to prevent or reduce POD. The primary outcome was the incidence of POD. We performed a network meta-analysis and used the surface under the cumulative ranking curve (SUCRA) values and rankograms to present the hierarchy of the pharmacological interventions evaluated.

Results

According to the SUCRA val

SUBMITTER: Lee JM 

PROVIDER: S-EPMC7861905 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature