Ex Situ Dual Hypothermic Oxygenated Machine Perfusion for Human Split Liver Transplantation.

ABSTRACT: Liver splitting allows the opportunity to share a deceased graft between 2 recipients but remains underutilized. We hypothesized that liver splitting during continuous dual hypothermic oxygenated machine perfusion (DHOPE) is feasible, with shortened total cold ischemia times and improved logistics. Here, we describe a left lateral segment (LLS) and extended right lobe (ERL) liver split procedure during continuous DHOPE preservation with subsequent transplantation at 2 different centers.

Methods

After transport using static cold storage, a 51-year-old brain death donor liver underwent end-ischemic DHOPE. During DHOPE, the donor liver was maintained <10 °C and oxygenated with a Po₂ of >106 kPa. An ex situ ERL/LLS split was performed with continuing DHOPE throughout the proc

SUBMITTER: Thorne AM 

PROVIDER: S-EPMC7862033 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature