Acute exercise impacts AhR and PD-1 levels of CD8⁺ T-cells-Exploratory results from a randomized cross-over trial comparing endurance versus resistance exercise.

ABSTRACT:

Purpose

The programmed cell death protein 1 (PD-1) has become a promising target in cancer immunotherapy. PD-1 expression of CD8⁺ T-cells may be increased via the exploitation of aryl hydrocarbon receptor (AhR) signaling with kynurenine (KYN) as a ligand. Since exercise affects KYN metabolism, we exploratory investigated the influence of acute exercise bouts on AhR and PD-1 levels of CD8⁺ T-cells.

Method

In this study, 24 healthy males (age: 24.6 ± 3.9 years; weight 83.9 ± 10.5 kg; height: 182.4 ± 6.2 cm) completed a single bout of endurance (EE) and resistance exercise (RE) in a randomly assigned order on separate days. Blood samples were drawn before (t0), after (t1), and 1 h after (t2) both conditions. T-cell populations, the level of cytoplasmic AhR

SUBMITTER: Schenk A 

PROVIDER: S-EPMC7862188 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature