Model-Informed Precision Dosing of Everolimus: External Validation in Adult Renal Transplant Recipients.

ABSTRACT:

Background and objective

The immunosuppressant everolimus is increasingly applied in renal transplantation. Its extensive pharmacokinetic variability necessitates therapeutic drug monitoring, typically based on whole-blood trough concentrations (C₀). Unfortunately, therapeutic drug monitoring target attainment rates are often unsatisfactory and patients with on-target exposure may still develop organ rejection. As everolimus displays erythrocyte partitioning, haematocrit-normalised whole-blood exposure has been suggested as a more informative therapeutic drug monitoring marker. Furthermore, model-informed precision dosing has introduced options for more sophisticated dose adaptation. We have previously developed a mechanistic population pharmacokinetic model, which descr

SUBMITTER: Zwart TC 

PROVIDER: S-EPMC7862213 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature