Pupillometry as a reliable metric of auditory detection and discrimination across diverse stimulus paradigms in animal models.

ABSTRACT: Estimates of detection and discrimination thresholds are often used to explore broad perceptual similarities between human subjects and animal models. Pupillometry shows great promise as a non-invasive, easily-deployable method of comparing human and animal thresholds. Using pupillometry, previous studies in animal models have obtained threshold estimates to simple stimuli such as pure tones, but have not explored whether similar pupil responses can be evoked by complex stimuli, what other stimulus contingencies might affect stimulus-evoked pupil responses, and if pupil responses can be modulated by experience or short-term training. In this study, we used an auditory oddball paradigm to estimate detection and discrimination thresholds across a wide range of stimuli in guinea pigs. We demo

SUBMITTER: Montes-Lourido P 

PROVIDER: S-EPMC7862232 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature