Cell and tissue system capable of automated culture, stimulation, and monitor with the aim of feedback control of organs-on-a-chip.

ABSTRACT: This paper presents progress in the automation of cell and tissue systems and attempts toward the in situ feedback control of organs-on-a-chip. Our study aims to achieve feedback control of a cell and tissue system by a personal computer (PC), whereas most studies on organs-on-a-chip focus on the automation of status monitoring. The implemented system is composed of subsystems including automated culture, stimulation, and monitoring. The monitoring function provides imaging as well as sampling and dispensing in combination with an external analyzer. Individual subsystems can be combined accordingly. First, monitoring of skeletal muscle (SM) and adipose tissues using this system was demonstrated. The highlight of this paper is the application of the system to the feedback control of the lip

SUBMITTER: Konishi S 

PROVIDER: S-EPMC7862322 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature