Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression.

ABSTRACT: Despite the progress to understand inflammatory reactions, mechanisms causing their resolution remain poorly understood. Prostanoids, especially prostaglandin E₂ (PGE₂), are well-characterized mediators of inflammation. PGE₂ is produced in an inducible manner in macrophages (Mϕ) by microsomal PGE₂-synthase-1 (mPGES-1), with the notion that it also conveys pro-resolving properties. We aimed to characterize the role of mPGES-1 during resolution of acute, zymosan-induced peritonitis. Experimentally, we applied the mPGES-1 inhibitor compound III (CIII) once the inflammatory response was established and confirmed its potent PGE₂-blocking efficacy. mPGES-1 inhibition resulted in an incomplete removal of neutrophils and a concomitant increase

SUBMITTER: Rappl P 

PROVIDER: S-EPMC7862376 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature