Intrinsic disorder in protein domains contributes to both organism complexity and clade-specific functions.

ABSTRACT: Interestingly, some protein domains are intrinsically disordered (abbreviated as IDD), and the disorder degree of same domains may differ in different contexts. However, the evolutionary causes and biological significance of these phenomena are unclear. Here, we address these issues by genome-wide analyses of the evolutionary and functional features of IDDs in 1,870 species across the three superkingdoms. As the result, there is a significant positive correlation between the proportion of IDDs and organism complexity with some interesting exceptions. These phenomena may be due to the high disorder of clade-specific domains and the different disorder degrees of the domains shared in different clades. The functions of IDDs are clade-specific and the higher proportion of post-translational mo

SUBMITTER: Gao C 

PROVIDER: S-EPMC7862400 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature