Met1-linked ubiquitin signalling in health and disease: inflammation, immunity, cancer, and beyond.

ABSTRACT: Post-translational modification of proteins with ubiquitin (ubiquitination) provides a rapid and versatile mechanism for regulating cellular signalling systems. Met1-linked (or 'linear') ubiquitin chains have emerged as a key regulatory signal that controls cell death, immune signalling, and other vital cellular functions. The molecular machinery that assembles, senses, and disassembles Met1-linked ubiquitin chains is highly specific. In recent years, the thorough biochemical and genetic characterisation of the enzymes and proteins of the Met1-linked ubiquitin signalling machinery has paved the way for substantial advances in our understanding of how Met1-linked ubiquitin chains control cell signalling and biology. Here, we review current knowledge and recent insights into the role of Met1

SUBMITTER: Jahan AS 

PROVIDER: S-EPMC7862443 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature