The neuroprogressive nature of major depressive disorder: evidence from an intrinsic connectome analysis.

ABSTRACT: Major depressive disorder (MDD) is a prevailing chronic mental disorder with lifetime recurring episodes. Recurrent depression (RD) has been reported to be associated with greater severity of depression, higher relapse rate and prominent functioning impairments than first-episode depression (FED), suggesting the progressive nature of depression. However, there is still little evidence regarding brain functional connectome. In this study, 95 medication-free MDD patients (35 with FED and 60 with RD) and 111 matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (fMRI) scanning. After six months of treatment with paroxetine, 56 patients achieved clinical remission and finished their second scan. Network-based statistics analysis was used to explore the ch

SUBMITTER: Liu J 

PROVIDER: S-EPMC7862649 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature