The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring.

ABSTRACT: While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determinants of inter-individual variation in the mental health of mothers. Likewise, the in utero biological pathways by which variation in maternal mental health affects offspring development remain to be defined. Previous studies implicate lipids, consistent with a known influence on cognitive and emotional function, but the relevance for maternal mental health and offspring neurodevelopment is unclear. This study characterizes the placental and circulatory lipids in antenatal depression, as well as socio-emotional outcomes in the offspring. Targeted liquid chromatography-mass spectrometry covering 470 lipid species was performed on placenta from 186 women with low (n

SUBMITTER: Wong G 

PROVIDER: S-EPMC7862650 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature