The aptamer BT200 blocks von Willebrand factor and platelet function in blood of stroke patients.

ABSTRACT: The effect of conventional anti-platelet agents is limited in secondary stroke prevention, and their effects are blunted under high shear stress in the presence of increased levels of circulating von Willebrand factor (VWF). VWF is critically involved in thrombus formation at sites of stenotic extracranial/intracranial arteries. A third generation anti-VWF aptamer (BT200) has been generated which could be useful for secondary stroke prevention. To characterize the effects of BT200 in blood of patients with large artery atherosclerosis stroke (LAA). Blood samples were obtained from 33 patients with acute stroke or transient ischemic attack to measure inhibition of VWF activity and VWF-dependent platelet function. Patients who received clopidogrel or dual antiplatelet therapy did not differ

SUBMITTER: Kovacevic KD 

PROVIDER: S-EPMC7862663 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature