Dim Light at Night Impairs Daily Variation of Circulating Immune Cells and Renal Immune Homeostasis.

ABSTRACT: Dim light at night (dLAN) has become a pervasive part of the modern world, and growing evidence shows its association with increased health risks. Though this link is attributed to a disturbed circadian clock, the underlying mechanisms that can explain how circadian disruption from dLAN causes negative health effects remain unclear. Here, we exposed rats to a light-dark cycle (12:12 h) with low-intensity light at night (~2 lx) for 2 and 5 weeks and explored the steady-state pattern of circulating immune cells and renal immune-related markers, which are well controlled by the circadian clock. After 5 weeks, dLAN impaired the daily variation in several types of white blood cells, especially monocytes and T cells. Two-week dLAN caused a reduction in blood monocytes and altered gene expression

SUBMITTER: Okuliarova M 

PROVIDER: S-EPMC7862740 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature