Vaccination and the Risk of Childhood Cancer-A Systematic Review and Meta-Analysis.

ABSTRACT:

Introduction

Infections may play a role in the etiology of childhood cancer and immunizations may be protective because vaccinations stimulate the immune system. Observational studies reported inconsistent associations between vaccination and risk of childhood cancer. Since a synthesis of the evidence is lacking, we conducted a meta-analysis stratified by histological and site-specific cancer.

Methods

We performed a systematic review (CRD42020148579) following PRISMA guidelines and searched for literature in MEDLINE, Embase, and the Science Citation Index databases. We identified in three literature databases 7,594 different articles of which 35 met the inclusion criteria allowing for 27 analyses of 11 cancer outcomes after exposure to nine different types of vaccinations. W

SUBMITTER: Marron M 

PROVIDER: S-EPMC7862764 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature