Comprehensive Characterization of Immunological Profiles and Clinical Significance in Hepatocellular Carcinoma.

ABSTRACT:

Background

Therapies targeting immune molecules have rapidly been adopted and advanced the treatment of hepatocellular carcinoma (HCC). Nonetheless, no studies have reported a systematic analysis between immunological profiles and clinical significance in HCC.

Methods

We comprehensively investigated immune patterns and systematically correlated 22 types of both adaptive and innate immune cells with genomic characteristics and clinical outcomes based on 370 HCC patients from The Cancer Genome Atlas (TCGA) database through a metagene approach (known as CIBERSORT). Based on the Quantitative Pathology Imaging and Analysis System coupled with integrated high-dimensional bioinformatics analysis, we further independently validated six immune subsets (CD4⁺ T cells,

SUBMITTER: Tao P 

PROVIDER: S-EPMC7862794 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature