Evaluation of the Neonatal Sequential Organ Failure Assessment and Mortality Risk in Preterm Infants With Late-Onset Infection.

ABSTRACT:

Importance

Infection in neonates remains a substantial problem. Advances for this population are hindered by the absence of a consensus definition for sepsis. In adults, the Sequential Organ Failure Assessment (SOFA) operationalizes mortality risk with infection and defines sepsis. The generalizability of the neonatal SOFA (nSOFA) for neonatal late-onset infection-related mortality remains unknown.

Objective

To determine the generalizability of the nSOFA for neonatal late-onset infection-related mortality across multiple sites.

Design, setting, and participants

A multicenter retrospective cohort study was conducted at 7 academic neonatal intensive care units between January 1, 2010, and December 31, 2019. Participants included 653 preterm (<33 weeks) very low-birth-we

SUBMITTER: Fleiss N 

PROVIDER: S-EPMC7862993 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature