Effect of balanced crystalloids versus saline on urinary biomarkers of acute kidney injury in critically ill adults.

ABSTRACT:

Background

Recent trials have suggested use of balanced crystalloids may decrease the incidence of major adverse kidney events compared to saline in critically ill adults. The effect of crystalloid composition on biomarkers of early acute kidney injury remains unknown.

Methods

From February 15 to July 15, 2016, we conducted an ancillary study to the Isotonic Solutions and Major Adverse Renal Events Trial (SMART) comparing the effect of balanced crystalloids versus saline on urinary levels of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) among 261 consecutively-enrolled critically ill adults admitted from the emergency department to the medical ICU. After informed consent, we collected urine 36 ± 12 h after hospital admission and measu

SUBMITTER: Funke BE 

PROVIDER: S-EPMC7863046 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature