Increased expression of MUSASHI1 in epithelial breast cancer cells is due to down regulation of miR-125b.

ABSTRACT:

Background

Musashi1 (MSI1) is an oncogenic protein with a crucial role in the proliferation and characteristics of the epithelial cells in breast cancer. The change in expression of MSI1 has a role in solid tumor progression. There are different factors that regulate MSI1 expression in various cancer tissues including microRNAs which are considered as one of the most important of these factors. The aim of our study is identification of the molecular cause of maximal expression of MSI1 in epithelial breast cancer cell lines.

Results

Among predicted microRNAs, miR-125b, miR-637 and miR-802 were able to significantly reduce the luciferase activity. In addition, the relative expression of these three miRNAs were measured in the cancerous cell lines that results showed a signific

SUBMITTER: Forouzanfar M 

PROVIDER: S-EPMC7863248 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature