Age-dependent VDR peak DNA methylation as a mechanism for latitude-dependent multiple sclerosis risk.

ABSTRACT:

Background

The mechanisms linking UV radiation and vitamin D exposure to the risk of acquiring the latitude and critical period-dependent autoimmune disease, multiple sclerosis, is unclear. We examined the effect of vitamin D on DNA methylation and DNA methylation at vitamin D receptor binding sites in adult and paediatric myeloid cells. This was accomplished through differentiating CD34+ haematopoietic progenitors into CD14+ mononuclear phagocytes, in the presence and absence of calcitriol.

Results

Few DNA methylation changes occurred in cells treated with calcitriol. However, several VDR-binding sites demonstrated increased DNA methylation in cells of adult origin when compared to cells of paediatric origin. This phenomenon was not observed at other transcription factor bi

SUBMITTER: Ong LTC 

PROVIDER: S-EPMC7863270 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature