The longitudinal relationship between immune cell profiles and frailty in patients with breast cancer receiving chemotherapy.

ABSTRACT:

Background

Frailty is associated with an increased risk of chemotherapy toxicity. Cellular markers of inflammation can help identify patients with frailty characteristics. However, the role of cellular markers of inflammation in identifying patients at risk of developing chemotherapy-induced frailty and their clinical utility are not fully understood.

Methods

This study was a secondary analysis of a large nationwide cohort study of women with stage I-IIIC breast cancer (n = 581, mean age 53.4; range 22-81). Measures were completed pre-chemotherapy (T1), post-chemotherapy (T2), and 6 months post-chemotherapy (T3). Frailty was assessed at all three time points using a modified Fried score consisting of four self-reported measures (weakness, exhaustion, physical activity, and w

SUBMITTER: Gilmore N 

PROVIDER: S-EPMC7863416 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature