Distinct roles for the RNA-binding protein Staufen1 in prostate cancer.

ABSTRACT:

Background

Prostate cancer is one of the most common malignant cancers with the second highest global rate of mortality in men. During the early stages of disease progression, tumour growth is local and androgen-dependent. Despite treatment, a large percentage of patients develop androgen-independent prostate cancer, which often results in metastases, a leading cause of mortality in these patients. Our previous work on the RNA-binding protein Staufen1 demonstrated its novel role in cancer biology, and in particular rhabdomyosarcoma tumorigenesis. To build upon this work, we have focused on the role of Staufen1 in other forms of cancer and describe here the novel and differential roles of Staufen1 in prostate cancer.

Methods

Using a cell-based approach, three independent pros

SUBMITTER: Marcellus KA 

PROVIDER: S-EPMC7863451 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature