Estrogen and Androgen Receptor Inhibitors: Unexpected Allies in the Fight Against COVID-19.

ABSTRACT:

Translational relevance

No prophylactic treatments for COVID-19 have been clearly proven and found. In this pandemic context, cancer patients constitute a particularly fragile population that would benefit the best from such treatments, a present unmet need. TMPRSS2 is essential for COVID-19 replication cycle and it is under androgen control. Estrogen and androgen receptor dependent cues converge on TMPRSS2 regulation through different mechanisms of action that can be blocked by the use of hormonal therapies. We believe that there is enough body of evidence to foresee a prophylactic use of hormonal therapies against COVID-19 and this hypothesis can be easily tested on cohorts of breast and prostate cancer patients who follow those regimens. In case of pandemic, if the protective ef

SUBMITTER: Bravaccini S 

PROVIDER: S-EPMC7863556 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature