The ganglioside G_D2 as a circulating tumor biomarker for neuroblastoma.

ABSTRACT:

Background

G_D2 is a ganglioside that is ubiquitously expressed in the plasma membrane of neuroblastoma and is shed into the circulation.

Procedure

G_D2 was measured with a high-pressure liquid chromatography/tandem mass spectrometry assay in serum or plasma from 40 children without cancer (controls) and in biobanked samples from 128 (73 high-risk) children with neuroblastic tumors at diagnosis, 56 children with relapsed neuroblastoma, 14 children with high-risk neuroblastoma after treatment, and 8 to 12 children each with 10 other common childhood cancers at diagnosis.

Results

The C₁₈ (18 carbon fatty acid) lipoform was the predominant circulating form of G_D2 in controls and in patients with neuroblastoma. The median concentr

SUBMITTER: Balis FM 

PROVIDER: S-EPMC7863579 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature