Short-Duration Prednisolone in Children with Nephrotic Syndrome Relapse: A Noninferiority Randomized Controlled Trial.

ABSTRACT:

Background and objectives

In children with nephrotic syndrome, steroids are the cornerstone of therapy for relapse. The adequate duration and dosage of steroids, however, have not been an active area of research, especially in children with infrequently relapsing nephrotic syndrome. This study investigated the efficacy of an abbreviated regimen for treatment of a relapse in this population.

Design, setting, participants, & measurements

In a single-center, open-label, randomized controlled trial, we evaluated the efficacy of prednisolone as a "short regimen" (40 mg/m² on alternate days for 2 weeks) compared with "standard regimen" (40 mg/m² on alternate days for 4 weeks) for children aged 1-16 years who achieved remission of a relapse. The primary outcom

SUBMITTER: Kainth D 

PROVIDER: S-EPMC7863637 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature