Exome Chip Analyses and Genetic Risk for IgA Nephropathy among Han Chinese.

ABSTRACT:

Background and objectives

IgA nephropathy is the most common form of primary GN worldwide. The evidence of geographic and ethnic differences, as well as familial aggregation of the disease, supports a strong genetic contribution to IgA nephropathy. Evidence for genetic factors in IgA nephropathy comes also from genome-wide association patient-control studies. However, few studies have systematically evaluated the contribution of coding variation in IgA nephropathy.

Design, setting, participants, & measurements

We performed a two-stage exome chip-based association study in 13,242 samples, including 3363 patients with IgA nephropathy and 9879 healthy controls of Han Chinese ancestry. Common variant functional annotation, gene-based low-frequency variants analysis, differential

SUBMITTER: Zhou XJ 

PROVIDER: S-EPMC7863642 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature