Use of the Urine-to-Plasma Urea Ratio to Predict ADPKD Progression.

ABSTRACT:

Background and objectives

Predicting disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD) poses a challenge, especially in early-stage disease when kidney function is not yet affected. Ongoing growth of cysts causes maximal urine-concentrating capacity to decrease from early on. We therefore hypothesized that the urine-to-plasma urea ratio, as a reflection of the urine-concentrating capacity, can be used as a marker to predict ADPKD progression.

Design

The urine-to-plasma urea ratio was calculated by dividing concentrations of early morning fasting spot urine urea by plasma urea. First, this ratio was validated as surrogate marker in 30 patients with ADPKD who underwent a prolonged water deprivation test. Thereafter, association with kidn

SUBMITTER: Heida JE 

PROVIDER: S-EPMC7863649 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature