Post-translational regulation of the major drug transporters in the families of organic anion transporters and organic anion-transporting polypeptides.

ABSTRACT: The organic anion transporters (OATs) and organic anion-transporting polypeptides (OATPs) belong to the solute carrier (SLC) transporter superfamily and play important roles in handling various endogenous and exogenous compounds of anionic charge. The OATs and OATPs are often implicated in drug therapy by impacting the pharmacokinetics of clinically important drugs and, thereby, drug exposure in the target organs or cells. Various mechanisms (e.g. genetic, environmental, and disease-related factors, drug-drug interactions, and food-drug interactions) can lead to variations in the expression and activity of the anion drug-transporting proteins of OATs and OATPs, possibly impacting the therapeutic outcomes. Previous investigations mainly focused on the regulation at the transcriptiona

SUBMITTER: Lee W 

PROVIDER: S-EPMC7863896 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature