Naturally occurring hotspot cancer mutations in Gα₁₃ promote oncogenic signaling.

ABSTRACT: Heterotrimeric G-proteins are signaling switches broadly divided into four families based on the sequence and functional similarity of their Gα subunits: G_s, G_i/o, G_q/11, and G_12/13 Artificial mutations that activate Gα subunits of each of these families have long been known to induce oncogenic transformation in experimental systems. With the advent of next-generation sequencing, activating hotspot mutations in G_s, G_i/o, or G_q/11 proteins have also been identified in patient tumor samples. In contrast, patient tumor-associated G_12/13 mutations characterized to date lead to inactivation rather than activation. By using bioinformatic pathway analysis and signaling assays, here we identified cancer-associa

SUBMITTER: Maziarz M 

PROVIDER: S-EPMC7864081 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature